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These changes are knownto promote malignant cell transformation.
2009) is that the dura-tion of action of agents such as rocuronium oratracurium is signi?cantly longer than that ofetomidate. The mice demon-strated accelerated tumorigenesis and like mdm2 transgenic mice, displayed a tumorspectrum with a high percentage of sarcomas, distinct from the tumor spectrum seenwith p53 null mice.
On the other hand, demon-strating a correlation between biomarkers and clinical outcome is not as unproblem-atic in more complex or rare conditions where the pathophysiology and clinicalpicture is more intricate.
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